Dicer in immune cell development and function
نویسندگان
چکیده
منابع مشابه
Dicer is required for Sertoli cell function and survival.
Dicer is a key enzyme that processes microRNA precursors into their mature form, enabling them to regulate gene expression. Dicer null mutants die before gastrulation. To study Dicer function in testis development, we crossed mice carrying a conditional Dicer allele with an AMH-Cre transgenic line, thereby inactivating Dicer in Sertoli cells around embryonic day 14.0 (E14.0). Dicer null Sertoli...
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Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzy...
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Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indist...
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Description of Procedure or Service Populations Interventions Comparators Outcomes Individuals: With a solid organ transplant Interventions of interest are: Immune cell function assay Comparators of interest are: Standard monitoring of immunosuppression Relevant outcomes include: Overall survival Test accuracy Other test performance measures Morbid events Individuals: With a hem...
متن کاملDicer-dependent microRNA pathway controls invariant NKT cell development.
Invariant NK T (iNKT) cells are a separate lineage of T lymphocytes with innate effector functions. They express an invariant TCR specific for lipids presented by CD1d and their development and effector differentiation rely on a unique gene expression program. We asked whether this program includes microRNAs, small noncoding RNAs that regulate gene expression posttranscriptionally and play a ke...
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ژورنال
عنوان ژورنال: Immunological Investigations
سال: 2013
ISSN: 0882-0139,1532-4311
DOI: 10.3109/08820139.2013.863557